About this item
The OKT4 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells.
The OKT4 antibody is widely used as a phenotypic marker for CD4 expression. It is cross-reactive with CD4 in several non-human species, including Chimpanzee, Cynomolgus and Rhesus. This antibody recognizes a different epitope, and thus does not block binding of, the alternative Anti-Human CD4 antibody clone RPA-T4 (Reinherz EL, et al. 1979. Proc. Natl. Acad. Sci. 76:4061-4065).
Type: Primary
Antigen: CD4 (CD4 molecule)
Clonality: monoclonal
Clone: OKT4
Conjugation: APC (Allophycocyanin)
Epitope:
Host: Mouse
Isotype: IgG2b Kappa
Reactivity:
Specifications
- Catalog No:
- 20-0048-T100
- 20-0048-T500
- 20-0048-T025
- Antigen symbol:
- CD4
- CD4
- CD4
- Antigen name:
- CD4 molecule
- CD4 molecule
- CD4 molecule
- Antigen synonyms:
- L3T4|p55|CD4mut|Ly-4|W3/25
- L3T4|p55|CD4mut|Ly-4|W3/25
- L3T4|p55|CD4mut|Ly-4|W3/25
- Antibody type:
- Primary
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Monoclonal
- Conjugation:
- APC (Allophycocyanin)
- APC (Allophycocyanin)
- APC (Allophycocyanin)
- Clone:
- OKT4
- OKT4
- OKT4
- Reactivity:
- Cynomolgus monkey, Rhesus monkey, Chimpanzee, Human
- Cynomolgus monkey, Rhesus monkey, Chimpanzee, Human
- Cynomolgus monkey, Rhesus monkey, Chimpanzee, Human
- Host:
- Mouse
- Mouse
- Mouse
- Gene ID:
- 920
- 920
- 920
- Isotype:
- IgG2b kappa
- IgG2b kappa
- IgG2b kappa
- Western blot:
- Yes
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- Yes
- ImmunoPrecipitation:
- Yes
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Yes
- Flow cytometry:
- Yes
- Yes
- Yes
- Cross adsorption:
- none
- none
- none
- Storage temperature:
- Cool
- Cool
- Cool
- Shipping temperature:
- Ice
- Ice
- Ice
Specifications
Product Information
- Catalog #Supplier #PkAvailabilityPrice
- 20-0048-T10020-0048-T100100 Tests1 * 100 Tests337 złSpecifications:
More
Specifications
Antigen symbolCD4Antigen nameCD4 moleculeEnvironmentally PreferableAntigen synonymsL3T4|p55|CD4mut|Ly-4|W3/25Antibody typePrimaryClonalityMonoclonalConjugationAPC (Allophycocyanin)CloneOKT4ReactivityCynomolgus monkey, Rhesus monkey, Chimpanzee, HumanHostMouseGene ID920IsotypeIgG2b kappaWestern blotYesImmunoChemistryYesImmunoPrecipitationYesImmunoFluorescenceYesFlow cytometryYesCross adsorptionnoneStorage temperatureCoolShipping temperatureIce - 20-0048-T50020-0048-T500500 Tests1 * 500 Tests1 350 złSpecifications:
More
Specifications
Antigen symbolCD4Antigen nameCD4 moleculeEnvironmentally PreferableAntigen synonymsL3T4|p55|CD4mut|Ly-4|W3/25Antibody typePrimaryClonalityMonoclonalConjugationAPC (Allophycocyanin)CloneOKT4ReactivityCynomolgus monkey, Rhesus monkey, Chimpanzee, HumanHostMouseGene ID920IsotypeIgG2b kappaWestern blotYesImmunoChemistryYesImmunoPrecipitationYesImmunoFluorescenceYesFlow cytometryYesCross adsorptionnoneStorage temperatureCoolShipping temperatureIce - 20-0048-T02520-0048-T02525 Tests1 * 25 Tests155 złSpecifications:
More
Specifications
Antigen symbolCD4Antigen nameCD4 moleculeEnvironmentally PreferableAntigen synonymsL3T4|p55|CD4mut|Ly-4|W3/25Antibody typePrimaryClonalityMonoclonalConjugationAPC (Allophycocyanin)CloneOKT4ReactivityCynomolgus monkey, Rhesus monkey, Chimpanzee, HumanHostMouseGene ID920IsotypeIgG2b kappaWestern blotYesImmunoChemistryYesImmunoPrecipitationYesImmunoFluorescenceYesFlow cytometryYesCross adsorptionnoneStorage temperatureCoolShipping temperatureIce