The JES6-5H4 antibody binds to mouse Interleukin-2 (IL-2), a 17 kDa cytokine that is secreted by activated T cells. This cytokine acts as an autocrine stimulatory factor for T cell proliferation, differentiation and survival, as well as being an effective activator of B cells and inducer of NK cell cytotoxic functions. IL-2 plays a key modulatory role in the differentiation of T cells toward either Th17 or T regulatory (Treg) cell types and is important for Treg cell function. The IL-2 receptor (IL-2R) is a complex consisting of an IL-2R alpha chain (CD25), along with the IL-2R beta chain (CD122) and the common gamma chain (CD132). IL-2 may also bind with low affinity to the T cell surface protein CD25 alone, although this interaction does not induce cell signaling.
The JES6-5H4 antibody is extensively used for intracellular detection of IL-2 by flow cytometry, for detection of soluble cytokine in ELISA, and as a neutralising reagent in vitro and in vivo.
Type: Primary
Antigen: IL2 (interleukin 2)
Clonality: monoclonal
Clone: JES6-5H4
Conjugation: Biotin
Epitope:
Host: Rat
Isotype: IgG2b Kappa
Reactivity: Mouse
- Catalog No:
- 30-7021-U025
- 30-7021-U100
- Antigen symbol:
- IL2
- IL2
- Antigen name:
- Interleukin 2
- Interleukin 2
- Antigen synonyms:
- POIL2|TCGF|IL-2|lymphokine
- POIL2|TCGF|IL-2|lymphokine
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- Biotin
- Biotin
- Clone:
- JES6-5H4
- JES6-5H4
- Reactivity:
- Mouse
- Mouse
- Host:
- Rat
- Rat
- Gene ID:
- 16183
- 16183
- Isotype:
- IgG2b kappa
- IgG2b kappa
- ELISA:
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Flow cytometry:
- Yes
- Yes
- Neutralisation:
- Yes
- Yes
- Cross adsorption:
- none
- none
- Storage temperature:
- Cool
- Cool
- Shipping temperature:
- Ice
- Ice
- Tested applications:
- Flow Cytometry
- Flow Cytometry
Product Information
- Catalog #Supplier #SizePkAvailabilityPrice
- 30-7021-U02530-7021-U02525 µg25 µG1 * 25 µG235 złSupplier Article Number: 30-7021-U025Local Article Number: TNBO30-7021-U025
Specifications
Antigen symbolIL2Antigen nameInterleukin 2Environmentally PreferableAntigen synonymsPOIL2|TCGF|IL-2|lymphokineAntibody typePrimaryClonalityMonoclonalConjugationBiotinCloneJES6-5H4ReactivityMouseHostRatGene ID16183IsotypeIgG2b kappaELISAYesImmunoChemistryYesImmunoFluorescenceYesFlow cytometryYesNeutralisationYesCross adsorptionnoneStorage temperatureCoolShipping temperatureIceTested applicationsFlow Cytometry - 30-7021-U10030-7021-U100100 µg100 µG1 * 100 µG711 złSupplier Article Number: 30-7021-U100Local Article Number: TNBO30-7021-U100
Specifications
Antigen symbolIL2Antigen nameInterleukin 2Environmentally PreferableAntigen synonymsPOIL2|TCGF|IL-2|lymphokineAntibody typePrimaryClonalityMonoclonalConjugationBiotinCloneJES6-5H4ReactivityMouseHostRatGene ID16183IsotypeIgG2b kappaELISAYesImmunoChemistryYesImmunoFluorescenceYesFlow cytometryYesNeutralisationYesCross adsorptionnoneStorage temperatureCoolShipping temperatureIceTested applicationsFlow Cytometry