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Anti-APOB Mouse Monoclonal Antibody [clone: F2C3]

Dostawca: Thermo Fisher Scientific
PIEAMA514724EA 0 PLN
PIEAMA514724
Anti-APOB Mouse Monoclonal Antibody [clone: F2C3]
Przeciwciała
MA5-14724 targets Apolipoprotein B in ELISA, IP, and RIA applications and shows reactivity with Human samples. The MA5-14724 immunogen is purified human serum LDL. MA5-14724 detects Apolipoprotein B which has a predicted molecular weight of approximately 513 kDa. Product MA514724 is a smaller package size of MIA1605 (formerly sold as a Seradyn product). This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.

Type: Primary
Antigen: APOB
Clonality: Monoclonal
Clone: F2C3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human
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