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Anti-TBP Mouse Monoclonal Antibody [clone: 51841]

Dostawca: Thermo Scientific
Heat mediated antigen retrieval recommended prior to tissue staining. This antibody is predicted to react with chicken, cow, Xenopus laevis, chimpanzee and zebrafish based on sequence homology. Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.

Type: Primary
Antigen: TBP
Clonality: Monoclonal
Clone: 51841
Conjugation: Unconjugated
Host: Mouse
Isotype: IgG2a, kappa
Reactivity: Human, Mouse, Rat



Rozwiń / Zwiń
Rozmiar Ilość Numer katalogowy VWR Ilość
100 µg 250 µG PIEAMA514739 Blocked
Blocked Ten produkt jest zablokowany. Prosimy, skontaktuj się z Działem Obsługi Klienta, aby uzyskać więcej informacji.
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Antigen symbol TBP
Antigen name TATA-binding protein
Reactivity Human, Rat, Mouse
Conjugation Unconjugated
Clonality Monoclonal
Antibody type Primary
Clone 51841
Host Mouse
Isotype IgG2a, kappa
Western blot Yes
ImmunoChemistry Yes
ImmunoPrecipitation Yes
ImmunoFluorescence Yes
Flow cytometry Yes
ChIP Yes
Antigen synonyms MGC126055, HDL4, SCA17, RP1-191N21.3, TATA-box-binding protein, TFIID, MGC126054, TATA sequence-binding protein, transcription initiation factor TFIID TBP subunit, GTF2D1, TATA-box binding protein N-terminal domain, TATA-box factor, MGC117320, GTF2D
Gene ID 6908, 21374, 117526
Stężenie 1 mg/ml
Immunogen Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human TATA binding protein TBP.
Purification IgG fraction
Form Liquid
Storage buffer PBS, 0.4M arginine, 0.02% sodium azide, pH 7.4
Temperatura przechowywania -20° C, Avoid Freeze/Thaw Cycles
Shipping temperature Ice
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