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Anti-PAX5 Mouse Monoclonal Antibody [clone: 52588]

Dostawca: Thermo Scientific
For Western Blot, this antibody has non-specific bands at 50 kDa. This antibody is predicted to react with mouse based on sequence homology. This gene encodes a member of the paired box family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in ttranslocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Type: Primary
Antigen: PAX5
Clonality: Monoclonal
Clone: 52588
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b
Reactivity: Human



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ZAMÓW

Rozwiń / Zwiń
Rozmiar Ilość Numer katalogowy VWR Ilość
100 µg 100 µG PIEAMA514750 Blocked
Blocked Ten produkt jest zablokowany. Prosimy, skontaktuj się z Działem Obsługi Klienta, aby uzyskać więcej informacji.
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SPECYFIKACJE

Antigen symbol PAX5
Antigen name Paired box 5
Reactivity Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody type Primary
Clone 52588
Host Mouse
Isotype IgG2b
Western Blot Yes
Antigen synonyms B-cell lineage specific activator, BSAP, B-cell-specific transcription factor, paired box protein Pax-5, paired box homeotic gene 5, transcription factor PAX 5, B cell specific activator protein
Gene ID 5079
Stężenie 0.2 mg/ml
Immunogen Synthetic peptide conjugated to KLH derived from within residues 1 - 100 of Human PAX5.
Purification IgG fraction
Form Liquid
Storage Buffer PBS, 0.02% sodium azide, pH 7.4
Temperatura przechowywania Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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