MA5-15232 targets Trim5a in IHC and WB applications and shows reactivity with Human samples. The MA5-15232 immunogen is purified recombinant fragment of human trim5 alpha expressed in E. Coli. TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.
Type: Primary
Antigen: TRIM5A
Clonality: Monoclonal
Clone: 3B11H2
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human