MA5-15233 targets CD3 in FACS applications and shows reactivity with Human samples. The MA5-15233 immunogen is purified recombinant fragment of human CD3 expressed in E. Coli. The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Type: Primary
Antigen: CD3Z
Clonality: Monoclonal
Clone: 4D10A6
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human