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Anti-CHK1 Mouse Monoclonal Antibody [clone: 2G1D5]

Dostawca: Thermo Scientific
MA5-15239 targets CHK1 in WB applications and shows reactivity with Human and mouse samples. The MA5-15239 immunogen is purified recombinant fragment of CHK1 expressed in E. Coli. MA5-15239 detects CHK1 which has a predicted molecular weight of approximately 56kDa. CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.

Type: Primary
Antigen: CHK1
Clonality: Monoclonal
Clone: 2G1D5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse



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ZAMÓW

Rozwiń / Zwiń
Rozmiar Ilość Numer katalogowy VWR Ilość
100 ug 100 µG PIEAMA515239 Blocked
Blocked Ten produkt jest zablokowany. Prosimy, skontaktuj się z Działem Obsługi Klienta, aby uzyskać więcej informacji.
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SPECYFIKACJE

Antigen symbol CHK1
Antigen name Checkpoint Kinase 1
Reactivity Mouse, Human
Conjugation Unconjugated
Clonality Monoclonal
Antibody type Primary
Clone 2G1D5
Host Mouse
Isotype IgG1
Western Blot Yes
Antigen synonyms CHK1, CHEK1
Gene ID 1111, 12649
Immunogen Purified recombinant fragment of CHK1 expressed in E. Coli.
Purification purified
Form Liquid
Storage Buffer PBS, 0.03% sodium azide
Temperatura przechowywania Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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