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Anti-RB1 Mouse Monoclonal Antibody [clone: 7E4B8]

Dostawca: Thermo Fisher Scientific
PIEAMA515240EA 0 PLN
PIEAMA515240
Anti-RB1 Mouse Monoclonal Antibody [clone: 7E4B8]
Przeciwciała
MA5-15240 targets RB in IHC applications and shows reactivity with Human samples. The MA5-15240 immunogen is purified recombinant fragment of human RB expressed in E. Coli. The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).

Type: Primary
Antigen: RB1
Clonality: Monoclonal
Clone: 7E4B8
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human
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