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Anti-ESRA Mouse Monoclonal Antibody [clone: 2B7]

Dostawca: Thermo Fisher Scientific
PIEAMA515268EA 0 PLN
PIEAMA515268
Anti-ESRA Mouse Monoclonal Antibody [clone: 2B7]
Przeciwciała
MA5-15268 targets ER-alpha in IHC and WB applications and shows reactivity with Human samples. The MA5-15268 immunogen is purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli. The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.

Type: Primary
Antigen: ESRA
Clonality: Monoclonal
Clone: 2B7
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human
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