MA5-15276 targets FGF2 in IHC and WB applications and shows reactivity with Human samples. The MA5-15276 immunogen is purified recombinant fragment of FGF2 expressed in E. Coli. The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Type: Primary
Antigen: FGF2
Clonality: Monoclonal
Clone: 2H5G2C11
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human