About this item
The SK3 antibody reacts with human CD4, a 59 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4, and co-receptors CCR5 and CXCR4, may also be utilized by HIV-1 to enter T cells. Human CD4 is typically expressed on thymocytes, some mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The SK3 antibody is widely used as a phenotypic marker for human CD4 expression, and has been reported to be cross-reactive with Rhesus and Cynomolgus CD4. This antibody does not block binding of alternative clone RPA-T4, suggesting that they recognize different epitopes.
Type: Primary
Antigen: CD4
Clonality: Monoclonal
Clone: SK3
Conjugation: PerCP (Peridinin-Chlorophyll Protein Complex)
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
Specifications
- Catalog No:
- 67-0047-T100
- 67-0047-T500
- 67-0047-T025
- Antigen symbol:
- CD4
- CD4
- CD4
- Antigen name:
- CD4 molecule
- CD4 molecule
- CD4 molecule
- Antigen synonyms:
- L3T4|p55|CD4mut|Ly-4|W3/25
- L3T4|p55|CD4mut|Ly-4|W3/25
- L3T4|p55|CD4mut|Ly-4|W3/25
- Antibody type:
- Primary
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Monoclonal
- Conjugation:
- PerCP (Peridinin-Chlorophyll Protein Complex)
- PerCP (Peridinin-Chlorophyll Protein Complex)
- PerCP (Peridinin-Chlorophyll Protein Complex)
- Clone:
- SK3
- SK3
- SK3
- Reactivity:
- Human
- Human
- Human
- Host:
- Mouse
- Mouse
- Mouse
- Gene ID:
- 920
- 920
- 920
- Isotype:
- IgG1 kappa
- IgG1 kappa
- IgG1 kappa
- Flow cytometry:
- Yes
- Yes
- Yes
- Cross adsorption:
- No
- No
- No
- Storage temperature:
- Store undiluted at 2-8 °C, protect from light, do not freeze.
- Store undiluted at 2-8 °C, protect from light, do not freeze.
- Store undiluted at 2-8 °C, protect from light, do not freeze.
Specifications
Product Information
- Catalog #Supplier #PkAvailabilityPrice
- Supplier Article Number: 67-0047-T100Local Article Number: TNBO67-0047-T100Specifications:
More
Specifications
Antigen symbolCD4Antigen nameCD4 moleculeEnvironmentally PreferableAntigen synonymsL3T4|p55|CD4mut|Ly-4|W3/25Antibody typePrimaryClonalityMonoclonalConjugationPerCP (Peridinin-Chlorophyll Protein Complex)CloneSK3ReactivityHumanHostMouseGene ID920IsotypeIgG1 kappaFlow cytometryYesCross adsorptionNoStorage temperatureStore undiluted at 2-8 °C, protect from light, do not freeze. - Supplier Article Number: 67-0047-T500Local Article Number: TNBO67-0047-T500Specifications:
More
Specifications
Antigen symbolCD4Antigen nameCD4 moleculeEnvironmentally PreferableAntigen synonymsL3T4|p55|CD4mut|Ly-4|W3/25Antibody typePrimaryClonalityMonoclonalConjugationPerCP (Peridinin-Chlorophyll Protein Complex)CloneSK3ReactivityHumanHostMouseGene ID920IsotypeIgG1 kappaFlow cytometryYesCross adsorptionNoStorage temperatureStore undiluted at 2-8 °C, protect from light, do not freeze. - Supplier Article Number: 67-0047-T025Local Article Number: TNBO67-0047-T025Specifications:
More
Specifications
Antigen symbolCD4Antigen nameCD4 moleculeEnvironmentally PreferableAntigen synonymsL3T4|p55|CD4mut|Ly-4|W3/25Antibody typePrimaryClonalityMonoclonalConjugationPerCP (Peridinin-Chlorophyll Protein Complex)CloneSK3ReactivityHumanHostMouseGene ID920IsotypeIgG1 kappaFlow cytometryYesCross adsorptionNoStorage temperatureStore undiluted at 2-8 °C, protect from light, do not freeze.