About this item
CD46 acts as a cofactor for complement factor I, a serine protease, which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells, which induces the differentiation of CD4 into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
Type: Primary
Antigen: CD46
Clonality: Monoclonal
Clone: 122.2
Conjugation: CF647
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
Specifications
- Catalog No:
- BNC470175-500
- BNC470175-100
- Antigen symbol:
- CD46
- CD46
- Antigen synonyms:
- Trophoblast leucocyte common antigen|Membrane cofactor protein|Complement membrane cofactor protein|MIC10|MCP|AHUS2|TLX|CD46 antigen complement regulatory protein|Measles virus receptor
- Trophoblast leucocyte common antigen|Membrane cofactor protein|Complement membrane cofactor protein|MIC10|MCP|AHUS2|TLX|CD46 antigen complement regulatory protein|Measles virus receptor
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 647
- CF® 647
- Clone:
- Clone 122.2
- Clone 122.2
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 510402
- 510402
- Isotype:
- IgG1 kappa
- IgG1 kappa
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Product Information
- Catalog #Supplier #SizePkAvailabilityPrice
- Specifications:
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Specifications
Antigen symbolCD46Environmentally PreferableAntigen synonymsTrophoblast leucocyte common antigen|Membrane cofactor protein|Complement membrane cofactor protein|MIC10|MCP|AHUS2|TLX|CD46 antigen complement regulatory protein|Measles virus receptorAntibody typePrimaryClonalityMonoclonalConjugationCF® 647CloneClone 122.2ReactivityHumanHostMouseGene ID510402IsotypeIgG1 kappaImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide - Specifications:
More
Specifications
Antigen symbolCD46Environmentally PreferableAntigen synonymsTrophoblast leucocyte common antigen|Membrane cofactor protein|Complement membrane cofactor protein|MIC10|MCP|AHUS2|TLX|CD46 antigen complement regulatory protein|Measles virus receptorAntibody typePrimaryClonalityMonoclonalConjugationCF® 647CloneClone 122.2ReactivityHumanHostMouseGene ID510402IsotypeIgG1 kappaImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide