About this item
Estrogen receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of ligand-activated transcription factors. Estrogen receptors, including ER-alpha and ER-beta, contain DNA binding and ligand binding domains and are critically involved in regulating the normal function of reproductive tissues. They are located in the nucleus, though some estrogen receptors associate with the cell surface membrane and can be rapidly activated by exposure of cells to estrogen. ER-alpha and ER-beta are differentially activated by various ligands. Receptor-ligand interactions trigger a cascade of events, including dissociation from heat shock proteins, receptor dimerization, phosphorylation and the association of the hormone activated receptor with specific regulatory elements in target genes. Evidence suggests that ER-alpha and ER-beta may be regulated by distinct mechanisms even though they share many functional characteristics.
Type: Primary
Antigen: ESR2
Clonality: Monoclonal
Clone: Clone ESR2/686
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human
Specifications
- Catalog No:
- BNC880686-100
- BNC880686-500
- Antigen symbol:
- ESR2
- ESR2
- Antigen name:
- Estrogen Receptor beta 1
- Estrogen Receptor beta 1
- Antigen synonyms:
- ESR BETA|estrogen nuclear receptor beta variant b|estrogen receptor 2 (ER beta)|estrogen nuclear receptor beta variant a|ESR2|ESRB|Erb|estrogen receptor beta 4|ESTRB
- ESR BETA|estrogen nuclear receptor beta variant b|estrogen receptor 2 (ER beta)|estrogen nuclear receptor beta variant a|ESR2|ESRB|Erb|estrogen receptor beta 4|ESTRB
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 488A
- CF® 488A
- Clone:
- Clone ESR2/686
- Clone ESR2/686
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 660607
- 660607
- Isotype:
- IgG2a
- IgG2a
- Western blot:
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Product Information
- Catalog #Supplier #SizePkAvailabilityPrice
- Specifications:
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Specifications
Antigen symbolESR2Antigen nameEstrogen Receptor beta 1Environmentally PreferableAntigen synonymsESR BETA|estrogen nuclear receptor beta variant b|estrogen receptor 2 (ER beta)|estrogen nuclear receptor beta variant a|ESR2|ESRB|Erb|estrogen receptor beta 4|ESTRBAntibody typePrimaryClonalityMonoclonalConjugationCF® 488ACloneClone ESR2/686ReactivityHumanHostMouseGene ID660607IsotypeIgG2aWestern blotYesImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide - Specifications:
More
Specifications
Antigen symbolESR2Antigen nameEstrogen Receptor beta 1Environmentally PreferableAntigen synonymsESR BETA|estrogen nuclear receptor beta variant b|estrogen receptor 2 (ER beta)|estrogen nuclear receptor beta variant a|ESR2|ESRB|Erb|estrogen receptor beta 4|ESTRBAntibody typePrimaryClonalityMonoclonalConjugationCF® 488ACloneClone ESR2/686ReactivityHumanHostMouseGene ID660607IsotypeIgG2aWestern blotYesImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide