Reacts with a 70 kDa membrane-bound isozyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. It is highly specific for PLAP and shows no cross-reaction with other isozymes of alkaline phosphatase. Anti-PLAP reacts with germ cell tumors and can discriminate between these and other neoplasms. Somatic neoplasms e.g. breast, gastrointestinal, prostatic, and urinary cancers may also immunoreact with antibodies to PLAP. Anti-PLAP positivity in conjunction with anti-keratin negativity favors seminoma over carcinoma. Germ cell tumors are usually anti-keratin positive, but they regularly fail to stain with anti-EMA, whereas most carcinomas stain with anti-EMA. Anti-PLAP has been useful in the diagnosis of gestational trophoblastic disease.
Type: Primary
Antigen: ALPP
Clonality: Monoclonal
Clone: PL8-F6
Conjugation: Purified
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human
- Catalog No:
- BNUB0889-100
- BNUB0889-500
- Antigen symbol:
- ALPP
- ALPP
- Antigen name:
- PLAP
- PLAP
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- Unconjugated
- Unconjugated
- Clone:
- Clone PL8-F6
- Clone PL8-F6
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 284255
- 284255
- Isotype:
- IgG2b kappa
- IgG2b kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,2 mg/ml
- 0,2 mg/ml
- Storage buffer:
- PBS/0,05% BSA/0,05% azide
- PBS/0,05% BSA/0,05% azide
- SizePk
- : BNUB0889-100: BTIUBNUB0889-100
Specifications
Antigen symbolALPPAntigen namePLAPEnvironmentally PreferableAntibody typePrimaryClonalityMonoclonalConjugationUnconjugatedCloneClone PL8-F6ReactivityHumanHostMouseGene ID284255IsotypeIgG2b kappaImmunoChemistryYesImmunoFluorescenceYesConcentration0,2 mg/mlStorage bufferPBS/0,05% BSA/0,05% azide - : BNUB0889-500: BTIUBNUB0889-500
Specifications
Antigen symbolALPPAntigen namePLAPEnvironmentally PreferableAntibody typePrimaryClonalityMonoclonalConjugationUnconjugatedCloneClone PL8-F6ReactivityHumanHostMouseGene ID284255IsotypeIgG2b kappaImmunoChemistryYesImmunoFluorescenceYesConcentration0,2 mg/mlStorage bufferPBS/0,05% BSA/0,05% azide