About this item
Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.
Type: Primary
Antigen: TYR
Clonality: Monoclonal
Clone: T311 OCA1/812
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgG
Reactivity: Human
Specifications
- Catalog No:
- BNC680908-100
- BNC680908-500
- Antigen symbol:
- TYR
- TYR
- Antigen name:
- Tyrosinase
- Tyrosinase
- Antigen synonyms:
- Tumor rejection antigen AB|ATN|CMM8|SHEP3|Oculocutaneous albinism IA|Monophenol monooxygenase|OCA1A|OCA1|TYR|LB24-AB|SK29-AB
- Tumor rejection antigen AB|ATN|CMM8|SHEP3|Oculocutaneous albinism IA|Monophenol monooxygenase|OCA1A|OCA1|TYR|LB24-AB|SK29-AB
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 568
- CF® 568
- Clone:
- Clone T311 OCA1/812
- Clone T311 OCA1/812
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 503555
- 503555
- Isotype:
- IgG
- IgG
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Product Information
- Catalog #Supplier #SizePkAvailabilityPrice
- Specifications:
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Specifications
Antigen symbolTYRAntigen nameTyrosinaseEnvironmentally PreferableAntigen synonymsTumor rejection antigen AB|ATN|CMM8|SHEP3|Oculocutaneous albinism IA|Monophenol monooxygenase|OCA1A|OCA1|TYR|LB24-AB|SK29-ABAntibody typePrimaryClonalityMonoclonalConjugationCF® 568CloneClone T311 OCA1/812ReactivityHumanHostMouseGene ID503555IsotypeIgGImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide - Specifications:
More
Specifications
Antigen symbolTYRAntigen nameTyrosinaseEnvironmentally PreferableAntigen synonymsTumor rejection antigen AB|ATN|CMM8|SHEP3|Oculocutaneous albinism IA|Monophenol monooxygenase|OCA1A|OCA1|TYR|LB24-AB|SK29-ABAntibody typePrimaryClonalityMonoclonalConjugationCF® 568CloneClone T311 OCA1/812ReactivityHumanHostMouseGene ID503555IsotypeIgGImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide