Product Details

Anti-CYCS Mouse Monoclonal Antibody (CF568) [clone: CYCS/1010]

Supplier: Biotium

Anti-CYCS Mouse Monoclonal Antibody (CF568) [clone: CYCS/1010]

Supplier: Biotium

About this item

Cytochrome C is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total cytochrome C which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).

Type: Primary
Antigen: CYCS
Clonality: Monoclonal
Clone: CYCS/1010
Conjugation: CF568
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human, Rat

Specifications

Catalog No:
BNC681010-500
BNC681010-100

Antigen symbol:
CYCS
CYCS

Antigen name:
Cytochrome C
Cytochrome C

Antigen synonyms:
HCS|THC4|CYCS|CYC
HCS|THC4|CYCS|CYC

Antibody type:
Primary
Primary

Clonality:
Monoclonal
Monoclonal

Conjugation:
CF® 568
CF® 568

Clone:
Clone CYCS/1010
Clone CYCS/1010

Reactivity:
Human, Rat
Human, Rat

Host:
Mouse
Mouse

Gene ID:
437060
437060

Isotype:
IgG2b kappa
IgG2b kappa

Western blot:
Yes
Yes

ImmunoChemistry:
Yes
Yes

ImmunoFluorescence:
Yes
Yes

Concentration:
0,1 mg/ml
0,1 mg/ml

Storage buffer:
PBS/0,1% BSA/0,05% azide
PBS/0,1% BSA/0,05% azide

Specifications

Product Information

Catalog #
Supplier #
Size
Pk
Availability
Price
BNC681010-500
BNC681010-500
500 μL
500 µl
Log in for availability
Log in for availability
1 * 500 µl
1 * 500 µl - 2 860 zł
2 860 zł
1 * 500 µl
2 860 zł
Supplier Article Number: BNC681010-500
Local Article Number: BTIUBNC681010-500
Specifications:
More
Specifications
Antigen symbol
CYCS
Antigen name
Cytochrome C
Environmentally Preferable
Antigen synonyms
HCS|THC4|CYCS|CYC
Antibody type
Primary
Clonality
Monoclonal
Conjugation
CF® 568
Clone
Clone CYCS/1010
Reactivity
Human, Rat
Host
Mouse
Gene ID
437060
Isotype
IgG2b kappa
Western blot
Yes
ImmunoChemistry
Yes
ImmunoFluorescence
Yes
Concentration
0,1 mg/ml
Storage buffer
PBS/0,1% BSA/0,05% azide
BNC681010-100
BNC681010-100
100 μL
100 µl
Log in for availability
Log in for availability
1 * 100 µl
1 * 100 µl - 1 040 zł
1 040 zł
1 * 100 µl
1 040 zł
Supplier Article Number: BNC681010-100
Local Article Number: BTIUBNC681010-100
Specifications:
More
Specifications
Antigen symbol
CYCS
Antigen name
Cytochrome C
Environmentally Preferable
Antigen synonyms
HCS|THC4|CYCS|CYC
Antibody type
Primary
Clonality
Monoclonal
Conjugation
CF® 568
Clone
Clone CYCS/1010
Reactivity
Human, Rat
Host
Mouse
Gene ID
437060
Isotype
IgG2b kappa
Western blot
Yes
ImmunoChemistry
Yes
ImmunoFluorescence
Yes
Concentration
0,1 mg/ml
Storage buffer
PBS/0,1% BSA/0,05% azide