About this item
This antibody recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.
Type: Primary
Antigen: FCGR3A
Clonality: Monoclonal
Clone: C16/1045
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG1, kappa
Reactivity: Human
Specifications
- Catalog No:
- BNC401045-100
- BNC401045-500
- Antigen symbol:
- FCGR3A
- FCGR3A
- Antigen name:
- CD16
- CD16
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 640R
- CF® 640R
- Clone:
- Clone C16/1045
- Clone C16/1045
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 372679
- 372679
- Isotype:
- IgG1 kappa
- IgG1 kappa
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Product Information
- Catalog #Supplier #SizePkAvailabilityPrice
- Specifications:
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Specifications
Antigen symbolFCGR3AAntigen nameCD16Environmentally PreferableAntibody typePrimaryClonalityMonoclonalConjugationCF® 640RCloneClone C16/1045ReactivityHumanHostMouseGene ID372679IsotypeIgG1 kappaImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide - Specifications:
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Specifications
Antigen symbolFCGR3AAntigen nameCD16Environmentally PreferableAntibody typePrimaryClonalityMonoclonalConjugationCF® 640RCloneClone C16/1045ReactivityHumanHostMouseGene ID372679IsotypeIgG1 kappaImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide