This antibody recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
Type: Primary
Antigen: TFF1
Clonality: Monoclonal
Clone: TFF1/1091
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human, Monkey
Specifications
- Catalog No:
- BNC881091-500
- BNC881091-100
- Antigen symbol:
- TFF1
- TFF1
- Antigen name:
- pS2
- pS2
- Antigen synonyms:
- Trefoil Factor 1|Gastrointestinal trefoil protein pS2|HPS2|BCEI|Gastrointestinal Trefoil Protein|HP1A|TFF1|pNR2|Breast Cancer Estrogen Inducible Protein
- Trefoil Factor 1|Gastrointestinal trefoil protein pS2|HPS2|BCEI|Gastrointestinal Trefoil Protein|HP1A|TFF1|pNR2|Breast Cancer Estrogen Inducible Protein
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 488A
- CF® 488A
- Clone:
- Clone TFF1/1091
- Clone TFF1/1091
- Reactivity:
- Monkey, Human
- Monkey, Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 162807
- 162807
- Isotype:
- IgG1 kappa
- IgG1 kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Specifications
Product Information
- Catalog #Supplier #SizePkAvailabilityPrice
- BNC881091-500BNC881091-500500 μL500 µl1 * 500 µl2 860 złSpecifications:
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Specifications
Antigen symbolTFF1Antigen namepS2Environmentally PreferableAntigen synonymsTrefoil Factor 1|Gastrointestinal trefoil protein pS2|HPS2|BCEI|Gastrointestinal Trefoil Protein|HP1A|TFF1|pNR2|Breast Cancer Estrogen Inducible ProteinAntibody typePrimaryClonalityMonoclonalConjugationCF® 488ACloneClone TFF1/1091ReactivityMonkey, HumanHostMouseGene ID162807IsotypeIgG1 kappaImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide - BNC881091-100BNC881091-100100 μL100 µl1 * 100 µl1 040 złSpecifications:
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Specifications
Antigen symbolTFF1Antigen namepS2Environmentally PreferableAntigen synonymsTrefoil Factor 1|Gastrointestinal trefoil protein pS2|HPS2|BCEI|Gastrointestinal Trefoil Protein|HP1A|TFF1|pNR2|Breast Cancer Estrogen Inducible ProteinAntibody typePrimaryClonalityMonoclonalConjugationCF® 488ACloneClone TFF1/1091ReactivityMonkey, HumanHostMouseGene ID162807IsotypeIgG1 kappaImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide