Informacje o tym produkcie
This antibody recognizes a 45 kDa protein, which is identified as isocitrate dehydrogenase (IDH1). It belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 catalyzes the third step of the citric acid cycle, which involves the oxidative decarboxylation of isocitrate, formingalpha-ketoglutarate and CO2 in a two-step reaction. The first step involves the oxidation of isocitrate to the intermediate oxalosuccinate, while the second step involves the production ofalpha-ketoglutarate. During this process, either NADH or NADPH is produced along with CO2. Recently, an inactivating mutation of IDH1 has been implicated in glioblastoma. IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.
Type: Primary
Antigen: IDH1
Clonality: Monoclonal
Clone: IDH1/1152
Conjugation: CF640R
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
Dane techniczne
- Catalog No:
- BNC401152-100
- BNC401152-500
- Antigen symbol:
- IDH1
- IDH1
- Antigen name:
- Isocitrate dehydrogenase 1
- Isocitrate dehydrogenase 1
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 640R
- CF® 640R
- Clone:
- Clone IDH1/1152
- Clone IDH1/1152
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 593422
- 593422
- Isotype:
- IgG1 kappa
- IgG1 kappa
- Western blot:
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Dane techniczne
Informacje o produkcie
- Catalog #Supplier #SizePkDostępnośćCena
- BNC401152-100BNC401152-100100 μL100 µl1 * 100 µl1 040 zł: BNC401152-100: BTIUBNC401152-100
Specifications
Antigen symbolIDH1Antigen nameIsocitrate dehydrogenase 1Environmentally PreferableAntibody typePrimaryClonalityMonoclonalConjugationCF® 640RCloneClone IDH1/1152ReactivityHumanHostMouseGene ID593422IsotypeIgG1 kappaWestern blotYesImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide - : BNC401152-500: BTIUBNC401152-500
Specifications
Antigen symbolIDH1Antigen nameIsocitrate dehydrogenase 1Environmentally PreferableAntibody typePrimaryClonalityMonoclonalConjugationCF® 640RCloneClone IDH1/1152ReactivityHumanHostMouseGene ID593422IsotypeIgG1 kappaWestern blotYesImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide