Anti-TNFSF18 Rat Monoclonal Antibody [clone: MGTL 10]

Dostawca: ProSci
PRSI36-008EA 1520 PLN
Anti-TNFSF18 Rat Monoclonal Antibody [clone: MGTL 10]
GITRL is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis, . ). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T-cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

ELISA: (direct and indirect: 1:5,000-1:10,000). Flow Cytometry: (1:1,000). Optimal conditions must be determined individually for each application.

Type: Primary
Antigen: TNFSF18
Clonality: Monoclonal
Clone: MGTL 10
Conjugation: Unconjugated
Host: Rat
Isotype: IgG2a kappa
Reactivity: Mouse
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