Human Recombinant GITRL (soluble) (from HEK293 cells)

Dostawca: ProSci
PRSI90-011EA 2170 PLN
Human Recombinant GITRL (soluble) (from HEK293 cells)
GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis). GITRL is constitutively expressed and released as soluble form by solid tumours and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukaemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumours.

Fusion-Tag: DDDDK Tag

This recombinant proteins is for research use only.
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