4004 Results for: "Tyrphostin+AG-126"

Supplier: Apollo Scientific

MAPK/ERK Signalling Pathway

Supplier: Enzo Life Sciences

AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

Supplier: Enzo Life Sciences

Tyrphostin AG 527 ≥98% (by HPLC)

Supplier: Enzo Life Sciences

AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.

Supplier: Enzo Life Sciences

A potent inhibitor of EGF receptor kinase activity (IC50=0.8 µM). Inhibition is mixed competitive with ATP and substrate.

Supplier: Enzo Life Sciences

Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.

Supplier: Enzo Life Sciences

Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

Supplier: Enzo Life Sciences

EGFR inhibitor

Supplier: Enzo Life Sciences

A potent inhibitor of PDGF receptor tyrosine kinase (IC50=1 µM). Also inhibits FGF receptor tyrosine kinase and c-kit. Induces apoptosis in a small-cell lung cancer cell line (H526).

Supplier: Apollo Scientific

Very potent EGF receptor kinase (tyrosine kinase) inhibitor (IC50 = 3 nM). Very weak on PDGF receptor and HER2-NEU kinases (IC50 >100 uM). Eur. J. Biochem. 225: 1047-1053 (1994).

Supplier: Apollo Scientific

Tyrphostin 1 95%

Supplier: Enzo Life Sciences

An inactive tyrphostin, which may be used as a negative control.

Supplier: Thermo Fisher Scientific

1,2,6-Hexanetriol 96%

Supplier: Enzo Life Sciences

Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.

Supplier: Enzo Life Sciences

Tyrphostin 9 is a selective inhibitor of the PDGF receptor tyrosine kinase (IC50=1.2 µM). It is also a potent (10 nM) uncoupler of oxidative phosphorylation.

Supplier: Enzo Life Sciences

A potent inhibitor of EGF receptor kinase activity (IC50=3 µM).

Supplier: Thermo Fisher Scientific

1,2,6-Hexanetriol 97+%, Extra Pure

Supplier: Enzo Life Sciences

A potent inhibitor of EGF receptor kinase activity (IC50=35 µM).

Supplier: Thermo Fisher Scientific

Tyrphostin A23 99%

Supplier: Thermo Fisher Scientific

Tyrphostin C15

Supplier: Merck

1,2,6-Hexanetriol, Sigma-Aldrich®

Supplier: Thermo Fisher Scientific

Tyrphostin B46 ≥98%

Supplier: Apollo Scientific

cis-1,2,6-Trimethylpiperazine dihydrochloride

Supplier: Enzo Life Sciences

AG-494 is a member of the tyrphostin family of tyrosine kinase inhibitors and is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 µM) and EGF-dependent cell growth (IC50=6 µM). It selectively inhibits HER1 (EGF receptor) vs. HER1-2 receptor autophosphorylation (HER1: IC50=1.1 µM; HER1-2: IC50=45 µM). HER1-2 is a chimeric receptor consisting of the external HER1 domain fused to an internal HER2 domain. Blocks CDK2 activation and causescells to arrest at late G1 and during S phase.

Supplier: Merck

1,2,6-Hexanetriol for synthesis, Sigma-Aldrich®

Supplier: Enzo Life Sciences

NGF receptor inhibitor

Supplier: Enzo Life Sciences

Tyrosine kinase inhibitor. It has been shown to block TNFα induced cytotoxicity and to block glucocorticoid-induced COX-2 activity in human amnion cells (IC50=21μM). It is also reported to inhibit guanylyl cyclase.

Supplier: Apollo Scientific

1,2,6-Trimethyl-1H-indole-3-carbaldehyde 95%

Supplier: LGC Standards PROMOCHEM

3,3',4,4',5-Pentachlorobiphenyl (PCB No. 126)

Supplier: Merck

Silver 65 - 75% (Ag basis), colloidal, Sigma-Aldrich®